Sometimes drugs used to fight inflammation, which can be caused by a variety of diseases, can compromise or make the immune system less efficient.
A group of researchers, led by Qing Deng, assistant professor at the Department of Biological Sciences at Purdue University and student Alan Y. Hsu, has discovered a new mechanism by which you can counteract inflammation by suppressing, at least in part, this side problem.
Researchers have discovered that it is possible to suppress the migration of a particular type of white blood cells called neutrophils. These cells can travel in the tissues of the organs, for example to counteract pathogens, but they can also be the basis of the inflammation itself, which in itself can lead to injury or other harmful effects.
To suppress the migration of these white blood cells, scientists have created a particular genetic molecule called miR-199. It is a micro RNA that suppresses the action of an enzyme, called cycline-dependent kinase 2, or CDK2, which in turn slows down the migration of neutrophils.
According to Deng himself, this discovery indicates “miR-199 and CDK2 as new targets for the treatment of inflammatory disorders and introduces a pathway of function for CDK2 outside the regulation of the cell cycle.”
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